Premium
Leiomyosarcoma of the uterus
Author(s) -
Christopherson W. M.,
Williamson E. O.,
Gray L. A.
Publication year - 1972
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197206)29:6<1512::aid-cncr2820290615>3.0.co;2-k
Subject(s) - leiomyosarcoma , medicine , smooth muscle tumor , leiomyoma , sarcoma , incidence (geometry) , pleomorphism (cytology) , uterus , uterine leiomyoma , disease , pathology , immunohistochemistry , physics , optics
Histologic material from 153 cases of uterine tumors with prior diagnosis or suspicion of sarcoma was reviewed. On the basis of cellularity, pleomorphism, and mitotic counts, 81 smooth muscle tumors were divided into 32 leiomyosarcomas, 31 cellular leiomyomas, 17 bizarre leiomyomas, and one intravascular leiomyoma. Only one case among the 153 was lost to follow‐up. The average yearly instance rate for leiomyosarcoma was 0.67 per 100,000 women 20 years old and older. The incidence was significantly higher in Negroes than in Caucasians. The 5‐year survival rate was 20.7%; however, three of the six 5‐year survivors subsequently died of disease, and one is living with disease. Mitotic counts accurately separate leiomyosarcoma from cellular leiomyoma. No patient with fewer than five mitoses per 10 high‐power field died of disease. The average length of follow‐up was 12 years. In spite of the alarming histologic and cytologic features of bizarre leiomyomas no patient died of disease. Follow‐up averaged 11.2 years.