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Chromosome constitution of transitional cell carcinoma of the urinary bladder
Author(s) -
Spooner Mary E.,
Cooper Edward H.
Publication year - 1972
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197205)29:5<1401::aid-cncr2820290543>3.0.co;2-0
Subject(s) - ploidy , chromosome , karyotype , transitional cell carcinoma , urinary bladder , transitional cell , pathology , biology , medicine , cancer research , bladder cancer , cancer , genetics , gene
The chromosome constitution of 64 bladder tumors was examined. All well‐differentiated, moderately differentiated, and 20% of poorly differentiated tumors were in the diploid range (42–49 chromosomes); the remainder had high ploidy levels without a modal preference. There are no characteristic karyotypic abnormalities specific to transitional cell carcinomas. Evolution of karyotypic change was observed in several recurrent tumors. The stability of well‐differentiated and moderately differentiated tumors is discussed.