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Osteogenic sarcoma of the skull: A rare sequela of pituitary irradiation
Author(s) -
Sparagana M.,
Eells R. W.,
Stefani S.,
Jablokow V.
Publication year - 1972
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197205)29:5<1376::aid-cncr2820290539>3.0.co;2-1
Subject(s) - medicine , sequela , chromophobe cell , skull , sarcoma , complication , radiation therapy , surgery , craniotomy , pituitary adenoma , frontal bone , radiology , adenoma , pathology , clear cell , renal cell carcinoma
A patient received multiple courses of kilovoltage radiation therapy and underwent two transfrontal craniotomies, with incomplete removal of a chromophobe adenoma of the pituitary. Twenty‐one years after the initial irradiation, he developed osteogenic sarcoma of the frontal bone, a very rare complication. Only two similar cases could be found in the literature. The high total dose, repeated courses of irradiation, and surgically‐induced vascular changes in the frontal bone flap may all have contributed to development of the sarcoma.