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Leukocyte adenosine deaminase phenotypes in acute leukemia
Author(s) -
Bloom Gerald E.
Publication year - 1972
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197205)29:5<1357::aid-cncr2820290536>3.0.co;2-9
Subject(s) - adenosine deaminase , medicine , leukemia , acute leukemia , acute myeloblastic leukemia , acute monocytic leukemia , immunology , pathology , adenosine
Fourteen enzyme electrophoretic systems have been studied in the malignant cells of 20 patients with various types of acute leukemia. Although quantitative variations were frequently observed, no abnormal patterns were seen except with adenosine deaminase (ADA) in seven patients with acute myelomonocytic leukemia. In this type of leukemia, a slow moving band of ADA activity in addition to the normal pattern was observed. No patients with acute lymphoblastic leukemia, and only one of the five with acute myeloblastic leukemia showed this pattern. It is suggested that electrophoresis of ADA in cells from patients with acute leukemia may be a useful adjunct to other currently available methods for the categorization of this disease.