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Hepatic dysfunction associated with renal carcinoma
Author(s) -
Ramos Carlos V.,
Taylor Herbert B.
Publication year - 1972
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197205)29:5<1287::aid-cncr2820290524>3.0.co;2-g
Subject(s) - medicine , thrombocytosis , nephrectomy , hepatosplenomegaly , hepatic dysfunction , liver dysfunction , pathology , carcinoma , gastroenterology , kidney , disease , platelet
Although first described in 1961, the association of renal carcinoma with hepatosplenomegaly, hepatic dysfunction, and thrombocytosis remains unexplained and is still not widely recognized. Among the most recent 50 patients with renal carcinoma treated at the St. Louis University Hospitals, five had this constellation of findings. The median age, 59 years, was the same for patients with or without the syndrome; the lesions were histologically identical to renal carcinomas without hepatic dysfunction. None of the five patients had evidence of metastasis to the liver at the time of operation, and the liver was histologically normal in one patient from whom a biopsy was taken. The hepatic dysfunction, hepatomegaly, and thrombocytosis disappeared postoperatively in the four patients who underwent nephrectomy. It seems clear that a humoral mechanism is responsible for the hepatic and hematopoietic alterations, but the nature of the mechanism remains to be demonstrated.