Premium
Clear‐cell adenocarcinoma (“mesonephroma”) of the vagina. Three cases associated with maternal synthetic nonsteroid estrogen therapy
Author(s) -
Tsukada Yoshiaki,
Hewett William J.,
Barlow Joseph J.,
Pickren John W.
Publication year - 1972
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197205)29:5<1208::aid-cncr2820290512>3.0.co;2-s
Subject(s) - medicine , vagina , malignancy , estrogen , pregnancy , vaginal bleeding , radiation therapy , estrogen therapy , hormonal therapy , chemotherapy , gynecology , obstetrics , surgery , cancer , breast cancer , genetics , biology
Three cases of clear‐cell adenocarcinom of the vagina occurring in adolescence are reported. During embryonic development of all these patients, their mothers were treated with synthetic nonsteroid estrogen. This hormonal therapy during pregnancy should be considered potentially carcinogenic to the embryo and avoided whenever possible. Two of our 3 patients died 28 months and 13 months after primary surgical treatment and combined ionizing radiation therapy and chemotherapy, respectively. It is important to include malignancy in the differential diagnosis of vaginal bleeding in teenagers.