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Papillary adenoma of the nipple (florid papillomatosis, adenoma, adenomatosis). A clinicopathologic study
Author(s) -
Perzin Karl H.,
Lattes Raffaele
Publication year - 1972
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197204)29:4<996::aid-cncr2820290447>3.0.co;2-h
Subject(s) - medicine , papillomatosis , nipple discharge , adenoma , papilloma , lesion , biopsy , intraductal papilloma , carcinoma , nodule (geology) , pathology , breast cancer , cancer , mammography , paleontology , biology
Papillary adenoma (florid papillomatosis, adenoma, adenomatosis) of the nipple is an uncommon lesion which can be mistaken clinically for Paget's disease and pathologically be misinterpreted as an adenocarcinoma. Sixty‐five cases of this tumor have been reviewed and the clinical and pathologic features discussed. In 51 patients, the lesion was symptomatic, with the most frequent complaints being a nipple discharge and an ulcerated nipple surface. The most common findings, on physical examination, were an eroded, ulcerated, or crusted nipple and a palpable nodule. Paget's disease and intraductal papilloma were the most common clinical diagnoses. Pathologic diagnosis was made either by incisional or excisional biopsy. Treatment consisted either of local excision of the tumor or partial or total resection of the nipple. Only one patient had a local recurrence, probably because of an inadequate initial resection. One patient developed carcinoma of the same breast 17 years later, and 2 had carcinoma of the opposite breast. Papillary adenoma of the nipple appears to be a benign lesion without precancerous significance which can be treated successfully by limited local resection.