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Chondroblastoma of bone. A clinicopathologic and electron microscopic study
Author(s) -
Huvos Andrew G.,
Marcove Ralph C.,
Erlandson Robert A.,
Miké Valerie
Publication year - 1972
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197203)29:3<760::aid-cncr2820290332>3.0.co;2-u
Subject(s) - chondroblastoma , medicine , curettage , pathology , golgi apparatus , giant cell , aneurysmal bone cyst , cancellous bone , lesion , endoplasmic reticulum , anatomy , chemistry , biochemistry
Twenty‐five patients with benign chondroblastoma of bone were treated at Memorial Sloan‐Kettering Cancer Center, from 1920 to 1970. The 15 male and 10 female patients, with an age range of 9 to 51 years, were treated by amputation, block excision, curettage, cryosurgery, and irradiation. The follow‐up period ranged up to 35 years with extremely slow gradual healing as demonstrated by sequential roentgenograms. No malignant transformation had occurred; however, one case exhibited soft tissue implantation. The lesion was characterized by a high recurrence rate of 38%. In 24% of all cases, aneurysmal bone cyst was engrafted on the tumor, resulting in a significantly higher recurrence rate. In 2 cases, electron microscopic examination revealed multiple small Golgi complexes, numerous electron‐lucent mitochondria, dilated segments of rough endoplasmic reticulum, and small bundles of cytoplasmic filaments, in the cytoplasm of the tumor cells. Patches of glycogen were also seen in some of the chondroblasts. The nuclei were irregularly shaped, and some were also multilobulated. A fibrous lamina was closely applied to the inner surface of the nuclear envelope of the chondroblasts.