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Comparative studies on localized leukocyte mobilization in patients with chronic myelocytic leukemia
Author(s) -
Banerjee Tarit K.,
Senn Hansjoerg,
Holland James F.
Publication year - 1972
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197203)29:3<637::aid-cncr2820290317>3.0.co;2-2
Subject(s) - medicine , complete remission , gastroenterology , leukemia , myelocytic leukemia , mobilization , chemotherapy , archaeology , history
Using autologous serum as medium, localized leukocyte mobilization into a plastic chamber at the site of mechanical abrasion was quantified in 5 patients with florid CML, one patient with chronic eosinophilic leukemia in the florid state, 3 patients (5 studies) with CML and partial response (remission or relapse), 6 patients with CML in good remission, and in 7 patients with CML in die blastic phase. The cumulative total number of cells was expressed as total leukocyte mobilization (TLM) × 10 6 /cm 2 at 24 hrs. Leukocyte clearance/cm 2 in 24 hrs. was expressed in milliliters of blood and was obtained by dividing TLM (corrected for non‐granulocytes) by the absolute granulocyte count in the peripheral blood. Although the median TLM was found to be elevated in CML with florid disease (130 × 10 6 /cm 2 at 24 hrs.) and in CML with partial remission and relapse (104 × 10 6 ), it fell to 74 × 10 6 in 6 patients in remission. This is to be compared with the median TLM for 46 normal subjects (76 × 10 6 /cm 2 at 24 hrs.). Median leukocyte clearances showed the lowest values in CML in the florid state (1.0 ml/cm 2 in 24 hrs), improving to 4.4 ml when a partial response was present, and to 9.3 ml in remission. This compares with 19.7 ml/cm 2 in 24 hours for 46 normal subjects. The median TLM in 7 patients with CML in blastic phase was 14 × 10 6 /cm 2 at 24 hrs., and the leukocyte clearance was reduced to 1.4 ml. These data suggest a defect in cell‐migration in all stages of CML, which is inversely correlated with clinical state. The data reinforce the reported prolongation of circulation time of leukocytes in CML, and suggest a mechanism for this in the impaired ability of CML leukocytes to migrate across the vessel wall.