Premium
Effect of beta‐aminopropionitrile on tumor metastases in the rat
Author(s) -
Gordon Mark,
Zykorie Stuart,
Gardner Bernard,
Patti Joseph,
Gray Henry
Publication year - 1972
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197202)29:2<509::aid-cncr2820290242>3.0.co;2-l
Subject(s) - medicine , collagenase , beta (programming language) , saline , sarcoma , pathology , lung , enzyme , biochemistry , chemistry , computer science , programming language
Rats treated with either beta‐aminoproprionitrile or saline received intramesenteric venous Walker sarcoma. Results showed no differences in hepatic takes but a significant increase in pulmonary metastases in BAPN‐treated animals. Bone collagenase levels were the same in both groups. Histologic studies revealed a disruptive influence of BAPN on collagen integrity of large vessels. The results imply that the lung is more sensitive to this effect than liver.