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Acinic cell tumor of the lung. A histologic and ultrastructural study
Author(s) -
Fechner R. E.,
Bentinck B. R.,
Askew J. B.
Publication year - 1972
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197202)29:2<501::aid-cncr2820290241>3.0.co;2-b
Subject(s) - acinic cell carcinoma , pathology , serous fluid , medicine , salivary gland , parotid gland , cell , ultrastructure , anatomy , biology , mucoepidermoid carcinoma , genetics
This is the first description, to our knowledge, of a primary neoplasm of the lower respiratory tract having the cytologic appearance of a salivary gland acinic cell tumor. When examined by light microscopy, the cells have cytoplasmic granules which are positive with PAS and negative with mucicarmine, alcian blue, and Masson‐Fontana stains. Ultrastructurally, two cell types are seen: a dark cell resembling the normal serous cell of the bronchial submucosal gland and a light cell similar to the cells of previously reported acinic cell tumors of the parotid. It seems likely that the lesion described herein originated from the serous cell of the bronchial submucosal gland and can be designated as an acinic cell tumor analogous to that occurring in the salivary gland. Salivary gland acinic cell tumors are histologically distinctive neoplasms which may have their metastases appear more than 10 years after removal of the primary. Our patient is well nearly 2 years after lobectomy.