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Hypersensitivity to procarbazine (Matulane ® ) manifested by fever and pleuropulmonary reaction
Author(s) -
Jones Stephen E.,
Moore Melvin,
Blank Norman,
Castellino Ronald A.
Publication year - 1972
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197202)29:2<498::aid-cncr2820290240>3.0.co;2-o
Subject(s) - procarbazine , medicine , pleural effusion , hypersensitivity reaction , eosinophilia , dermatology , pleurisy , chemotherapy , pathology , immunology , surgery , vincristine , cyclophosphamide
Three cases of hypersensitivity to oral procarbazine (Matulane ® ) are described. All occurred during 4‐drug combination chemotherapy of Hodgkin's disease. Two reactions primarily involved the skin. The third patient manifested recurrent fever, pulmonary infiltration, pleural effusion, and eosinophilia ultimately demonstrated to be secondary to procarbazine on controlled challenge. The pertinent literature is reviewed.