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Radiotherapy plus 5‐Fu compared to radiotherapy alone for inoperable and unresectable bronchogenic carcinoma
Author(s) -
Carr David T.,
Childs Donald S.,
Lee Robert E.
Publication year - 1972
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197202)29:2<375::aid-cncr2820290218>3.0.co;2-h
Subject(s) - medicine , radiation therapy , carcinoma , adenocarcinoma , survival rate , oncology , radiology , cancer
One hundred and eighty‐eight patients with inoperable or unresectable bronthogenic carcinoma, classified by cell type and extent of disease, were randomly allocated to radiotherapy alone or to radiotherapy plus 5‐FU. Results of therapy, evaluated primarily by survival rates, revealed no significant improvement by the addition of 5‐FU. For example, the survival rates at 12 months for patients with squamous cell carcinoma were 32% after radiotherapy alone and 36% after radiotherapy plus 5‐FU. Comparable survival rates for patients with adenocarcinoma were 42% and 60%; for patients with small cell carcinoma, 19% and 23%; and for patients with large cell undifferentiated carcinoma, 31% and 28%. Our data reveal that the regimen of 5‐FU and radiotherapy is not significantly more effective than radiotherapy alone in the treatment of inoperable or unresectable bronchogenic carcinoma.