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Association of atypical characteristics of benign breast lesions with subsequent risk of breast cancer
Author(s) -
Black Maurice M.,
Barclay Thomas H. C.,
Cutler Sidney J.,
Hankey Benjamin F.,
Asire Ardyce J.
Publication year - 1972
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197202)29:2<338::aid-cncr2820290212>3.0.co;2-u
Subject(s) - medicine , breast cancer , grading (engineering) , atypia , retrospective cohort study , mammary gland , lesion , oncology , gynecology , pathology , cancer , civil engineering , engineering
A retrospective case‐control study was carried out to determine to what degree atypical changes in the mammary duct system are associated with increased risk of developing breast cancer. A previously developed grading system was used by one of us (MMB) to describe the morphological atypicality in a series of benign breast lesions. Our primary finding is that a woman with some degree of ductular atypia in a benign lesion is subject to a risk of developing breast cancer 5 times that of a woman with no evidence of atypical changes. The implications of this finding regarding treatment require further study.