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Transitional cell carcinoma of the prostate. A clinical morphological study
Author(s) -
Johnson Douglas E.,
Hogan John M.,
Ayala Alberto G.
Publication year - 1972
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197202)29:2<287::aid-cncr2820290204>3.0.co;2-q
Subject(s) - medicine , prostate , transitional cell carcinoma , carcinoma , lesion , radiation therapy , pathology , stroma , stoma (medicine) , transitional cell , urinary bladder , urology , radiology , surgery , cancer , bladder cancer , immunohistochemistry
Transitional cell carcinoma of the prostate developed in 6 patients without an antecedent history of a vesical malignant lesion or a coexisting bladder tumor. The diagnosis was established late in the disease and treatment with radiotherapy did not appear to improve survival. In 14 other patients, prostatic lesions were noted either at the time of treatment for a noncontiguous bladder lesion (10 patients) or asynchronously in patients with previous bladder malignancies (4 patients). Conservative treatment is advocated if the lesions are confined to the ductal epithelium. Radical treatment using either radiotherapy, surgical extirpation, or a combination of both is indicated when stroma invasion is documented. Careful histologic examination of the tissue from these 20 patients suggests that in both groups of patients the lesions began as carcinoma in situ in the prostatic ductal epithelium with subsequent breakthrough into the prostatic stoma.