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Benign breast disease in women on estrogen therapy. A pathologic study
Author(s) -
Fechner Robert E.
Publication year - 1972
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197202)29:2<273::aid-cncr2820290202>3.0.co;2-8
Subject(s) - medicine , fibrocystic disease , hyperplasia , estrogen , fibrocystic breast disease , disease , hormone replacement therapy (female to male) , breast tissue , menopause , atypical hyperplasia , gynecology , breast cancer , hormone , breast disease , estrogen therapy , hormone therapy , pathology , cancer , testosterone (patch)
Breast tissue has been examined from 43 women taking estrogens for menopausal symptoms or post‐menopausal replacement therapy. Two of the patients had typical fibroadenomas. Tissue from the remaining patients presented the spectrum of fibrocystic disease. Slides from these 41 cases were coded and mixed with slides from age‐matched patients with fibrocystic disease who denied hormone usage. A variety of epithelial patterns were tabulated without knowing the status of hormone usage. The patients taking estrogens had a slightly greater frequency of epithelial hyperplasia (39%) compared to the controls (32%). No qualitative differences were detected between the 2 groups and the slight variation in frequency of hyperplasia is judged to be insignificant.