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Poor prognosis in negro children with acute lymphocytic leukemia
Author(s) -
Walters Thomas R.,
Bushore Martha,
Simone Joseph
Publication year - 1972
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197201)29:1<210::aid-cncr2820290131>3.0.co;2-u
Subject(s) - medicine , leukemia , chemotherapy , pediatrics , acute lymphocytic leukemia , el niño , disease , complete remission , natural history , lymphoblastic leukemia
This study of 334 children with acute lymphocytic leukemia was undertaken to compare the clinical course and response to chemotherapy of Negro children with those of Caucasian children. An initial hematologic remission was attained in 34 of 46 Negro children (74%) with a median duration of the first hematologic remission of 4.9 months and median survival of 14 months. In Caucasian children, a remission occurred in 265 of 288 (92%) with a median duration of 13.1 months and a median survival of 23 months. The poor prognosis in Negro children was related to advanced disease and poverty. However, the natural history of leukemia in the Negro children suggested that other factors related to race also influence host‐disease interaction. Because of the difference in response, Negro children should be considered separately in designing and evaluating chemotherapy programs.