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Serum copper correlations with bone marrow
Author(s) -
Tessmer Carl F.,
Hrgovcic Martin,
Brown Barry W.,
Wilbur Jordan,
Thomas Forrest B.
Publication year - 1972
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197201)29:1<173::aid-cncr2820290127>3.0.co;2-1
Subject(s) - medicine , bone marrow , acute leukemia , copper , leukemia , pathology , endocrinology , chemistry , organic chemistry
A study of 346 bone marrow samples and serum copper levels obtained on the same day from 112 patients with acute leukemia shows highly significant relationships between serum copper levels and cellular components of the bone marrow. Of these, the relationship between percentage of blast cells and serum copper is the most important, in view of the significance of blast cells as an index of disease activity and their role in management of leukemias. The relationship may be expressed in terms of probability (Fig. 9), although the model utilized does not appear to define the relationship fully. The findings were most striking in the pediatric group. However, the relationship is quite similar in the adult group. Pediatric values were demonstrated to coincide with adult data by application of an age‐correction factor. The serum copper level is proposed as an important value for the management of acute leukemia.