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Ultrastructure of hemangioendothelial sarcoma of bone
Author(s) -
Steiner German C.,
Dorfman Howard D.
Publication year - 1972
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197201)29:1<122::aid-cncr2820290120>3.0.co;2-u
Subject(s) - ultrastructure , extravasation , pathology , sarcoma , infiltration (hvac) , pericyte , anatomy , medicine , cytoplasm , biology , microbiology and biotechnology , endothelial stem cell , materials science , biochemistry , in vitro , composite material
Abstract The ultrastructural findings in a case of well‐differentiated hemangioendothelial sarcoma of bone are described. The tumor vessels are lined by plump endothelial cells, with a larger number of organelles than their normal counterparts. Discontinuities of the vessel wall with endothelial gaps are observed. Pericytes are present in the wall of the vessels, and some are loosely attached. A few fibroblasts and smooth muscle cells are seen. Transitional stages between fibroblasts and pericytes and between pericytes and smooth muscle cells are observed. The intervascular cellular infiltration is most likely the result of extravasation through gaps in the fragile neoplastic vessels. It is proposed that the pericytes are the main source of reticulum fibers in the tumor.