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Studies on virus particles resembling oncogenic RNA viruses in monkey breast carcinoma
Author(s) -
Chopra H. C.,
Zelljadt I.,
Woodside N.,
Walling M. J.
Publication year - 1971
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197112)28:6<1406::aid-cncr2820280613>3.0.co;2-#
Subject(s) - virus , virology , biology , nucleoid , cytoplasm , vacuole , cell culture , oncovirus , tissue culture , pathology , microbiology and biotechnology , in vitro , medicine , genetics , gene , biochemistry , escherichia coli
A spontaneous breast tumor from an 8‐year‐old rhesus monkey, Macaco, mulatto. , was investigated by electron microscopic and tissue culture techniques. Virus particles, morphologically resembling mouse mammary tumor virus, were detected in the tumor cells. The virus was isolated and propagated by cocultivation of the tumor tissue with the monkey embryo and monkey lung cells. Cell‐free virus was found to be infectious for rhesus monkey embryo cells, rhesus monkey lung cells, chimpanzee lung cells, normal human leukocytes, and human embryonic cells. The morphological, biochemical, and immunologic evidence indicates the oncogenic nature of this virus, yet the biologic activity of this virus is still unknown.