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Transmission of cancer in man: Tentative guidelines referring to the possible effects of inoculation of homologous cancer extracts in man
Author(s) -
Gross Ludwik
Publication year - 1971
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197109)28:3<785::aid-cncr2820280338>3.0.co;2-x
Subject(s) - inoculation , cancer , medicine , heterologous , transmission (telecommunications) , azathioprine , homologous chromosome , disease , prednisone , immunology , biology , gene , genetics , electrical engineering , engineering
Inoculation of humans with live human cancer extracts may lead to the establishment of progressively growing tumors in the recipients and cause dissemination of a fatal disease. Close relatives are particularly susceptible to the inoculation of tumors from genetically related donors. The results of inoculation of cancer extracts from human patients to unrelated human recipients are unpredictable. In rare instances, the implanted tumors may “take,” grow progressively, and lead to a generalization of the disease. Administration of immunosuppressive drugs, such as azathioprine or prednisone, lowers natural resistance of the host to heterologous tumors; patients receiving such treatment are particularly susceptible to transmission of human cancer.