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The fate of circulating methylcholanthrene tumor cells in mice with tumor‐specific immunity
Author(s) -
Wexler Hilda,
Chretien Paul B.,
Ketcham Alfred S.
Publication year - 1971
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197109)28:3<641::aid-cncr2820280316>3.0.co;2-n
Subject(s) - methylcholanthrene , immunity , tumor cells , medicine , immune system , cell , circulatory failure , inoculation , circulating tumor cell , pathology , circulatory system , lung , immunology , cancer research , biology , carcinogen , cancer , metastasis , genetics
Syngeneic mice were immunized to a methylcholanthrene‐induced tumor, and immunity was demonstrated by the failure of cell suspensions of the tumor to grow when inoculated intramuscularly. Identical cell suspensions inoculated intravenously, however, produced pulmonary tumors in all immunized animals. Intravenous inoculations of blood containing circulating tumor cells obtained from donor mice bearing the same tumor produced identical numbers of pulmonary tumors in immunized and unimmunized animals. Thus, in this well‐studied experimental model, specific immune inhibition of tumor growth as conventionally assessed was not reflected in destruction of cell suspensions of the tumor or circulating tumor cells shed from the tumor when these cells are injected into the circulatory system.