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Nuclear DNA content in hyperplastic lesions of cystic disease of the breast with special reference to malignant alteration
Author(s) -
Izuo Msaru,
Okagaki Takashi,
Richart Ralph M.,
Lattes Raffaele
Publication year - 1971
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197109)28:3<620::aid-cncr2820280314>3.0.co;2-y
Subject(s) - feulgen stain , ploidy , nuclear dna , pathology , dna , carcinoma , cell nucleus , distribution (mathematics) , biology , medicine , genetics , cytoplasm , staining , mitochondrial dna , mathematical analysis , mathematics , gene
The nuclear DNA content of epithelial cells in hyperplastic lesions from 15 cases of cystic disease of the breast were measured by Feulgen microspectrophotometry. The DNA distribution pattern was compared with the results of clinical follow‐up. Of the 15 cases of cystic disease, 8 subsequently developed carcinoma, and 7 cases did not. An aneuploid DNA distribution pattern was found in 3 cases (5 lesions) in the former group, whereas all cases in the second group had a diploid or diploid‐to‐tetraploid distribution. The 5 aneuploid lesions consisted of 2 instances of hyperdiploid, 2 hypodiploid, and 1 near‐diploid distribution pattern.