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Multiple lymphomatous polyposis of the gastrointestinal tract
Author(s) -
Sheahan D. G.,
Martin F.,
Baginsky S.,
Mallory G. Kenneth,
Zamcheck N.
Publication year - 1971
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197108)28:2<408::aid-cncr2820280222>3.0.co;2-u
Subject(s) - gastrointestinal tract , medicine , enteropathy , malignancy , immune system , protein losing enteropathy , lymphatic system , pathology , disease , immunology
This report describes the clinical course, the diagnosis and management, the apparent long‐term ineffectiveness of chemotherapy, and the radiological and morphological course of a case of multiple lymphomatous polyposis of the gastrointestinal tract studied over an 18‐month period. No evidence of a mal‐absorption state was found either early or late in the clinical course, but an apparent protein‐losing enteropathy without immunoelectrophoretic evidence of serum immunoglobulin change was disclosed. Lymphoepithelial relationships of the gastrointestinal tract are discussed. It is speculated that multiple lymphomatous polyposis of the gastrointestinal tract, a primary malignancy originating from and involving the lymphoid tissue of the gut, may represent the malignant counterpart in the humoral immune system of the malignant thymoma in the cellular immune system. Further inquiry into the role of the lymphoid system in the growth, maturation, function, and morphology of mucosal epithelia may be feasible through the study of patients with this form of lymphomatous disease.