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Ultrastructure of a fibroxanthosarcoma (malignant fibroxanthoma)
Author(s) -
Merkow Leonard P.,
Frich John C.,
Slifkin Malcolm,
Kyreages Constantine G.,
Pardo Matias
Publication year - 1971
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197108)28:2<372::aid-cncr2820280217>3.0.co;2-u
Subject(s) - atypical fibroxanthoma , medicine , ultrastructure , pathology , dermatology , immunohistochemistry
Primary and metastatic lesions from a fibroxanthosarcoma (FXS) originating in the neck of a 29‐year‐old Caucasian woman are reported. Light and electron microscopic observations are correlated to define the various types of cells constituting this neoplasm. Ultrastructural examination verified that several types of cells can act as facultative fibroblasts. Since a malignant potentiality cannot be predicted solely from the histopathology of fibroxanthomas, an attempt was made to categorize certain ultrastructural nuclear and cytoplasmic organelles associated with FXS cells. This was done in order to further define the malignant neoplastic cells of the FXS, so that distinguishing the malignant from benign forms of this neoplasm may become more feasible.