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Duration and severity of fatty metamorphosis of the liver following L‐asparaginase therapy
Author(s) -
Pratt Charles B.,
Johnson Warren W.
Publication year - 1971
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197108)28:2<361::aid-cncr2820280215>3.0.co;2-3
Subject(s) - medicine , metamorphosis , gastroenterology , incidence (geometry) , persistence (discontinuity) , asparaginase , endocrinology , oncology , leukemia , biology , lymphoblastic leukemia , botany , physics , geotechnical engineering , larva , optics , engineering
Histologic sections of liver obtained at postmortem examination from 31 patients who received L‐asparaginase therapy for various hematologic malignancies were reviewed to define the incidence, severity, and duration of fatty metamorphosis. Twenty‐seven of the patients had hepatic lipidosis of varying degrees of severity up to 261 days following the last dose of L‐asparaginase. The high frequency and the persistence of hepatic changes following L‐asparaginase could have an influence on subsequent therapy with other antileukemic agents that are metabolized by the liver or are themselves potentially hepatotoxic.