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Studies of polycyclic hydrocarbon hydroxylases of the intestine possibly related to cancer: Effect of diet on benzpyrene hydroxylase activity
Author(s) -
Wattenberg Lee W.
Publication year - 1971
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197107)28:1<99::aid-cncr2820280118>3.0.co;2-m
Subject(s) - carcinogen , inducer , enzyme , biochemistry , polycyclic aromatic hydrocarbon , biology , medicine , chemistry , food science , environmental chemistry , gene
The effect of dietary manipulation on the benzpyrene hydroxylase activity of the small intestine of the rat has been investigated. Most, and possibly all, of the benzpyrene hydroxylase activity in this site is due to exogenous inducers in the diet. Rats fed a balanced purified diet or starved for one day or more show virtually no activity. A beginning survey of dietary constituents has revealed that a number of vegetables, particularly those belonging to the Brassicaceae family, contain inducers. Data indicate that diet could be of importance in determining the response of organisms to exposures to poly cyclic hydrocarbon carcinogens.