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Cellular kinetics and their implications for chemotherapy of solid tumors, especially cancer of the colon
Author(s) -
Johnson Robert O.,
Wolberg William H.
Publication year - 1971
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197107)28:1<208::aid-cncr2820280141>3.0.co;2-7
Subject(s) - medicine , colorectal cancer , chemotherapy , cancer , solid tumor , gastrointestinal tract , drug , drug resistance , cancer research , cancer chemotherapy , haematopoiesis , cancer cell , gastrointestinal cancer , cell , oncology , immunology , pharmacology , stem cell , biology , genetics , microbiology and biotechnology
Basic and clinical studies of the kinetic and biochemical characteristics of normal and malignant cells have led to a better understanding of the problems of chemotherapy for solid tumors. These studies suggest that clinically we should concentrate on the treatment of small residuals of cancer for long periods of time by varied combinations of drug therapy, preferably using high doses of drug and avoiding development of resistant cells. It is desirable to develop better drugs both for antitumor effect and for manipulation of the cell cycle. Protective therapy for the hemopoietic and gastrointestinal tract might be very rewarding. Increasing host immunologic resistance may be the key to cure.