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Cause and prevention of recurrence following surgery for colon cancer
Author(s) -
Cohn Isidore
Publication year - 1971
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197107)28:1<183::aid-cncr2820280137>3.0.co;2-0
Subject(s) - medicine , anastomosis , fibrous joint , surgery , brachytherapy , cancer , suture line , radiation therapy
Tumor recurrence at the suture line is noted with sufficient frequency to be a cause for concern in all patients following surgery for cancer of the colon. An experimental model has been described and the method has been used to evaluate a variety of ways to control this type recurrence. Extensions of the method indicate that recurrence is dependent upon the cells being implanted on the serosal surface or else being implanted in the anastomotic area by the suture material, rather than by direct growth on the mucosal surface. A few techniques have a positive value in controlling tumor recurrence. Iodized suture is effective for control at the anastomosis. Control of peritoneal implantation may be obtained by irrigation with low molecular weight dextran or irradiation by conventional means or locally acting radioactive ceramic micro‐spheres. A closed anastomosis controls implantation in both areas. Clinical evaluation of the various means of control of tumor implantation and recurrence is urgently needed.