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Multiple primary tumors including bilateral breast cancers in a man with Klinefelter's syndrome
Author(s) -
Coley Geoffrey M.,
Otis Richard D.,
Clark William E.
Publication year - 1971
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197106)27:6<1476::aid-cncr2820270630>3.0.co;2-t
Subject(s) - klinefelter syndrome , medicine , gynecomastia , breast cancer , cancer , genetic syndromes , pathology , oncology , physiology , pediatrics
A 50‐year‐old man with Klinefelter's syndrome developed 6 histologically distinct tumors in sequence; five were considered to be malignant neoplasms. Others have reported an association between this syndrome and the development of neoplasms, especially cancer of the breast. The hormonal and genetic factors characteristic of patients with Klinefelter's syndrome may be important in the genesis of cancer.