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Electron microscopic study of papillary serous tumors of the ovary
Author(s) -
Gondos Bernard
Publication year - 1971
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197106)27:6<1455::aid-cncr2820270628>3.0.co;2-b
Subject(s) - pathology , ovary , serous fluid , medicine , malignancy , papillary tumor
Electron microscopic evaluation was performed in a series of papillary serous tumors of the ovary, including 4 cystadenomas, 2 cystadenocarcinomas, and 2 tumors with questionable histologic evidence of malignancy. Marked nuclear irregularity was found in the cells of those tumors which were malignant by histologic criteria. Nuclei of cells from benign tumors had a regular shape and outline, with only shallow indentations. In the cases with borderline malignant changes, an intermediate degree of nuclear irregularity was present. Many of the cells showed a marked degree of nuclear infolding, comparable to that of the frankly malignant tumors. A decreased amount of cell membrane interdigitation was observed in the malignant tumors as compared to the benign. The borderline group was intermediate in this respect. Cilia were present in the benign and borderline malignant tumors but were not seen in the frankly malignant tumors. The findings indicate that electron microscopic analysis may be a useful adjunct in the evaluation of papillary cystic tumors of the ovary.