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Immunologic response of mice bearing leukemia L1210
Author(s) -
Bonmassar Enzo,
Bonmassar Anna,
Vadlamudi Srikrishna,
Goldin Abraham
Publication year - 1971
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197106)27:6<1356::aid-cncr2820270613>3.0.co;2-r
Subject(s) - immunosuppression , leukemia , medicine , antibody response , immune system , immunology , antigen , antibody , neoplasm , pathology
The primary antibody response of mice bearing transplanted leukemias was studied using the direct plaque‐forming cell (PFC) technique. Decrease of the immune response was found in mice bearing advanced isogenic or allogeneic leukemia, whereas normal or even increased PFC response was seen when the antigenic stimulus was given at an early stage of the disease. Leukemia remission induced by 1,3‐bis(2‐chloroethyl)‐1‐nitrosourea (BCNU) did not prevent the immunosuppression of leukemic mice, although the same treatment schedule did not interfere with antibody production in nonleukemic animals.