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Successful remission induction in children with acute lymphocytic leukemia at high risk for treatment failure
Author(s) -
Aur Rhomes J. A.,
Simone Joseph V.,
Pratt Charles B.
Publication year - 1971
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197106)27:6<1332::aid-cncr2820270609>3.0.co;2-o
Subject(s) - medicine , prednisone , leukocytosis , azotemia , hepatosplenomegaly , vincristine , gastroenterology , leukemia , acute lymphocytic leukemia , tumor lysis syndrome , surgery , chemotherapy , disease , lymphoblastic leukemia , renal function , cyclophosphamide
Eleven children with untreated acute lymphocytic leukemia at high risk for treatment failure were given a combination of prednisone, vincristine, daunomycin, and L‐asparaginase for remission induction. Negro children and those with marked leukocytosis, hepatosplenomegaly, symptomatic visceral infiltration, or other evidence of advanced disease qualified for this study. All 11 patients achieved complete remission marrow in a median time of 18 days. Reversible drug toxicity attributable to L‐asparaginase included azotemia, hyperuricemia, hyperglycemia, hyperamylasemia, coagulation defects, and weight loss.