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Hypofibrinogenemia and coagulation factor deficiencies with L‐asparaginase treatment
Author(s) -
Gralnick Harvey R.,
Henderson Edward
Publication year - 1971
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197106)27:6<1313::aid-cncr2820270606>3.0.co;2-w
Subject(s) - hypofibrinogenemia , medicine , coagulation , fibrinogen , fibrinolysis , hemostasis , disseminated intravascular coagulation , gastroenterology , acute leukemia , leukemia
Thirteen patients with acute leukemia were treated with L‐asparaginase. Abnormalities of blood coagulation and fibrinolysis developed in all 13 patients. Decreased levels of fibrinogen, Factors V, VII‐X, VIII, and IX with decreased plasminogen concentration and fibrinogen degradation products in serum were the most common abnormalities. Two patients developed hemorrhagic or thrombotic complications related to this abnormal hemostasis. The underlying mechanism of these changes is thought to be limited disseminated intravascular coagulation combined with decreased synthesis of coagulation factors.