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Human carcinoma of the breast, in vitro: The effect of hormones. A preliminary report
Author(s) -
Burstein Nelson A.,
Kjellberg Raymond N.,
Raker John W.,
Schmidek Henry H.
Publication year - 1971
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197105)27:5<1112::aid-cncr2820270517>3.0.co;2-7
Subject(s) - hormone , human chorionic gonadotropin , testosterone (patch) , human breast , in vitro , medicine , breast carcinoma , endocrinology , carcinoma , gonadotropin , hormonal therapy , oncology , breast cancer , biology , cancer , biochemistry
Cortisol, estradiol‐17B, progesterone, testosterone, and human chorionic gonadotropin altered 3 H‐thymidine uptake in tissue culture suspensions of human breast carcinoma in 10 of 20 tumors studied. In 6 patients where there was an opportunity to observe the clinical response to hormonal therapy, an apparent correlation was present between the in vitro data and clinical course. This correlation suggests that this in vitro assay may be useful in selecting patients for hormonal therapy.