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Carcinoid islet cell tumor of the duodenum and associated multiple carcinoid tumors of the ileum. An electron microscopic study
Author(s) -
Weichert Rudolph F.,
Roth Lawrence M.,
Harkin James C.
Publication year - 1971
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197104)27:4<910::aid-cncr2820270423>3.0.co;2-x
Subject(s) - carcinoid tumors , duodenum , ileum , islet , pathology , medicine , pancreas , enterochromaffin cell , neuroendocrine cell , enteroendocrine cell , serotonin , immunohistochemistry , endocrine system , insulin , receptor , hormone
Light and electron microscopic studies were done on a carcinoid‐islet cell tumor of the duodenum and 8 carcinoid tumors of the ileum which were surgically excised from a patient with achalasia and a duodenal ulcer. By light microscopy, the duodenal tumor resembled both an islet cell tumor and a carcinoid of the type found in tissues of foregut origin; the ileal tumors had the typical characteristics of carcinoids of midgut origin. On electron microscopy, some cells of the duodenal tumor contained small round granules, which resemble the delta cell granules of the normal islets of Langerhans and the granules present in gastric carcinoid tumors. Other cells in the duodenal tumor contained large granules of low electron density. The ileal tumors contained polymorphic elongated secretory granules that were believed to contain serotonin. The association of this duodenal tumor, which had morphological characteristics of both a carcinoid and an islet cell tumor, with multiple carcinoids of the ileum and with a duodenal ulcer can be interpreted as giving further support to the concept that such duodenal tumors are related both to carcinoid and islet cell tumors.