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Facilitation of tumor growth by syngeneic normal cells mixed with tumor cells in vitro
Author(s) -
Deckers Peter J.,
Ramming Kenneth P.,
Pilch Yosef H.
Publication year - 1971
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197104)27:4<897::aid-cncr2820270421>3.0.co;2-d
Subject(s) - spleen , in vitro , in vivo , tumor cells , neoplasm , pathology , medicine , cancer research , immunology , biology , biochemistry , microbiology and biotechnology
Facilitated tumor growth was observed in syngeneic animals after the subcutaneous inoculation of these animals with normal syngeneic spleen cells and tumor cells previously mixed in vitro. Tumor incidence, latency, and growth rate appear quantitatively directly related to the ratio of spleen cells to tumor cells in the challenge inocular. This phenomenon was consistently demonstrated in two syngeneic murine tumor‐host systems and one sygeneic rat system. Facilitated tumor growth is not a specific property of the spleen cells in these mixtures. Mixtures of liver cells and tumor cells produce identical results. Reproducible facilitated growth of tumor isografts by mixture with normal spleen cells, however, must be considered in the design and interpretation of all in vivo neutralization experiments.