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Hypercalcemia in chronic granulocytic leukemia
Author(s) -
Haskell Charles M.,
Devita Vincent T.,
Canellos George P.
Publication year - 1971
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197104)27:4<872::aid-cncr2820270417>3.0.co;2-d
Subject(s) - medicine , chronic granulocytic leukemia , chronic renal failure , leukemia , chronic leukemia , metabolic disorder , acute leukemia , gastroenterology , pathology
Two patients with the accelerated phase of chronic granulocytic leukemia (CGL) complicated by hypercalcemia are described. Both patients had extensive leukemia, and it is likely that hypercalcemia was secondary to bone destruction. However, one of these patients also had acute renal failure and neither patient had measurements of plasma parathormone, so other mechanisms of hypercalcemia cannot be excluded entirely. On the basis of these patients and a review of the literature, we conclude that hypercalcemia rarely complicates CGL, that its presence appears to signify a grave prognosis, and that treatment should include antileukemic therapy as well as other measures known to help control hypercalcemia in malignant disorders.