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Chondrosarcoma. Immune reactions of a patient to autologous tumor
Author(s) -
Sinkovics Joseph G.,
Shirato Eiichi,
Martin Richard G.,
Cabiness Jerry R.,
White Edgar C.
Publication year - 1971
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197104)27:4<782::aid-cncr2820270405>3.0.co;2-m
Subject(s) - chondrosarcoma , medicine , antigen , immune system , pathology , antibody , cancer research , tumor cells , immunology
Chondrosarcoma cells obtained from the tumor of one patient were established in culture. The tumor cells contained filamentous structures resembling viral ribonucleoprotein strands. Autologous small lymphocytes reacted immediately with cultured tumor cells and inhibited the growth of the culture. Destruction of tumor cells by lymphocytes was seen; autologous fibroblasts were not damaged. Small lymphocytes of another patient with chondrosarcoma also reacted immediately with cultured allogeneic tumor cells and inhibited growth. Lymphocytes of normal donors reacted both with cultured fibroblastic and neoplastic cells of the patient but only after several days of co‐cultivation; blastic transformation of lymphocytes was evident during co‐cultivation. It is proposed that patients with chondrosarcoma circulate presensitized small “executor” lymphocytes committed to a tumor antigen. The patient's serum reacted with cytoplasmic antigens of the autologous tumor cells in an indirect fluorescent antibody test.