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Regional pulmonary function in metastatic carcinoma to the lung studied with xenon‐133
Author(s) -
Ali, M. Khalil,
Howe Clifton D.,
Miller John M.
Publication year - 1971
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197102)27:2<460::aid-cncr2820270234>3.0.co;2-g
Subject(s) - medicine , pulmonary function testing , lung , xenon , radiology , cardiology , arterial blood , shunt (medical) , pathology , physics , atomic physics
Lung function was studied in 21 patients with nodular pulmonary metastases. Routine pulmonary function studies demonstrated that reduction in vital capacity and arterial PO 2 , related to the degree of tumor involvement, are characteristic features of metastatic lung disease. The reduced arterial PO 2 is largely explained by increased right to left shunt. Regional pulmonary function studied with xenon‐133 and 8 scintillation detectors revealed frequent ventilatory defects in the vicinity of single metastases. In patients with multiple bilateral metastases, defects in pulmonary blood flow and ventilation were commonly observed in the vicinity of the tumor masses.