Premium
Cyclophosphamide and radiation therapy in the treatment of hemangioendothelioma with disseminated intravascular clotting
Author(s) -
AlRashid Rashid A.
Publication year - 1971
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197102)27:2<364::aid-cncr2820270219>3.0.co;2-v
Subject(s) - medicine , hemangioendothelioma , coagulopathy , cyclophosphamide , disseminated intravascular coagulation , radiation therapy , radiology , prednisone , clotting factor , consumptive coagulopathy , kasabach–merritt syndrome , abnormality , surgery , chemotherapy , psychiatry
An infant with a retroperitoneal hemangioendothelioma complicated by severe bleeding due to intravascular consumption coagulopathy is presented. Cyclophosphamide combined with prednisone and radiation therapy caused rapid cessation of bleeding and return of all coagulation factors to normal. This was associated with rapid regression of the tumor. The mechanism of the coagulation abnormality in vascular tumors is reviewed.