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Invasion of the brain by a cellular blue nevus of the scalp. A case report with light and electron microscopic studies
Author(s) -
Silverberg Gerald D.,
Kadin Marshall E.,
Dorfman Ronald F.,
Hanbery John W.,
Prolo Donald J.
Publication year - 1971
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197102)27:2<349::aid-cncr2820270216>3.0.co;2-r
Subject(s) - scalp , medicine , lesion , skull , meninges , pathology , blue nevus , nevus , dermatology , anatomy , melanoma , cancer research
Repeated biopsies of a large pigmented lesion of the scalp of a young boy over a six‐year period showed the characteristic features of a cellular blue nevus. Recent severe neurologic symptoms necessitated more radical surgical intervention. This disclosed focal invasion of the underlying skull, meninges, and brain. Apart from focal necrosis and multiple nucleoli in the most recent surgical specimen, the histologic features of the lesion have remained constant, despite its locally aggressive behavior. Electron microscopic studies demonstrated distinctive nucleolar configurations not previously reported.