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Proliferation and ultrastructure of papillary transitional cell carcinoma of the human bladder
Author(s) -
Fulker M. J.,
Cooper E. H.,
Tanaka T.
Publication year - 1971
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197101)27:1<71::aid-cncr2820270112>3.0.co;2-e
Subject(s) - colcemid , ultrastructure , pathology , epithelium , carcinoma , cytoplasm , human bladder , malignancy , urinary bladder , medicine , biology , microtubule , microbiology and biotechnology , bladder cancer , cancer
The ultrastructure of human bladder epithelium and bladder tumors has been examined with particular reference to the organization of well‐differentiated papillary carcinoma. Estimates of the potential growth rates of the tumors have been obtained, using the colcemid stathmokinetic technique. The relation of cell organization to rates of division is discussed. Tumors of low malignancy have many of the ultrastructural features of normal epithelium; invasive tumors have a more simple cytoplasm with loss of specialization of the surface cells' unit membrane and suppression of telolysosome formation.