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Vasoactive substances in Kaposi's sarcoma
Author(s) -
Bhana D.,
Hillier K.,
Karim S. M. N.
Publication year - 1971
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197101)27:1<233::aid-cncr2820270133>3.0.co;2-q
Subject(s) - medicine , histamine , sarcoma , itching , kaposi's sarcoma , diarrhea , edema , abdominal pain , serotonin , urine , prostaglandin , gastroenterology , pathology , dermatology , human herpesvirus , receptor
Nine patients with Kaposi's sarcoma had tumor tissue, blood, and urine examined for the presence of 5‐hydroxytryptamine (5HT), histamine, catecholamines, and prostaglandins to determine if an overproduction of any of these substances might be associated with some of the clinical features of the tumor. The features vary from pricking pains, itching, and increased local sweating to edema of the affected limb. In addition, a small percentage of patients develop gastrointestinal symptoms, such as abdominal pain and diarrhea. The results show that 5HT, histamine, and catecholamine concentrations were within normal limits. But prostaglandin‐like materials was found in all Kaposi's sarcoma tissue tested. The presence of this substance may explain the occurrence, in some patients with Kaposi's sarcoma, of persistent abdominal pain and diarrhea.