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Chromosomes and causation of human cancer and leukemia. VII. The significance of the Ph 1 in conditions other than CML
Author(s) -
Hossfeld Dieter K.,
Han Tin,
Holdsworth Robert N.,
Sandberg Avery A.
Publication year - 1971
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197101)27:1<186::aid-cncr2820270126>3.0.co;2-7
Subject(s) - chromosome , cancer , bone marrow , leukemia , medicine , pathology , cancer research , genetics , biology , immunology , gene
Two cases of Ph 1 ‐positive AML, and one case of Di Guglielmo's syndrome are reported. A review of the literature reveals that the occurrence of a Ph 1 ‐chromosome has been observed in a number of cases with these diseases, indicating that the Ph 1 ‐chromosome is not solely specific for CML. By correlating cytogenetic and histologic bone marrow data, some evidence is presented that the process leading to the genesis of a Ph 1 ‐chromosome may affect the bone marrow cells either at or beyond the stem cell level.