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Chromosomes and causation of human cancer and leukemia. VI. Blastic phase, cellular origin, and the Ph 1 in CML
Author(s) -
Sandberg Avery A.,
Hossfeld Dieter K.,
Ezdinli Ediz Z.,
Crosswhite Lois H.
Publication year - 1971
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197101)27:1<176::aid-cncr2820270125>3.0.co;2-b
Subject(s) - myelocytic leukemia , medicine , incidence (geometry) , stem cell , leukemia , cancer , pathology , immunology , cancer research , biology , genetics , physics , optics
The cytogenetic, histologic, and pertinent clinical data on 107 cases of CML from our laboratory and those from the literature on the incidence of Ph 1 ‐negative cells in marrows of patients with Ph 1 ‐positive CML have been collected and summarized. In addition, the distribution of multiple Ph 1 ‐chromosomes in 5 cases of CML, with and without the blastic phase, has been described and discussed. The findings served as a basis for caution in utilizing the high incidence of Ph 1 ‐positive cells in the marrows of the preponderant number of patients with CML as support for the unicellular stem cell origin of such cells. The occurrence of Ph 1 ‐negative cells in significant percentages in some patients with chronic myelocytic leukemia indicates that several other hypotheses, including a multi‐stem cell origin of marrow cells, are compatible with the observations in CML.