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Microchromosomes in human preleukemia and leukemia
Author(s) -
Pierre Robert V.,
Hoagland, H. Clark,
Linman James W.
Publication year - 1971
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197101)27:1<160::aid-cncr2820270124>3.0.co;2-x
Subject(s) - preleukemia , acute myelomonocytic leukemia , leukemia , clone (java method) , chronic myelomonocytic leukemia , medicine , bone marrow , acute leukemia , cancer research , biology , immunology , dna , genetics , myelodysplastic syndromes
Microchromosomes have been observed in direct bone‐marrow chromosome preparations in 9 patients. Seven of these patients had overt myelomonocytic leukemia, one had a preleukemic syndrome initially and subsequently had acute leukemia, and one is believed to be in the preleukemic phase of myelomonocytic leukemia. It is suggested that the microchromosomes in these cases are marker chromosomes which identify a clone or clones of leukemic cells. Microchromosomes appear to be frequent findings in myelomonocytic leukemia.