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Carbohydrate‐rich compounds in the colonic mucosa of man. II. Histochemical characteristics of colonic adenocarcinomas
Author(s) -
Korhonen L. Kalevi,
Mäkelä Veikko,
Lilius G.
Publication year - 1971
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197101)27:1<128::aid-cncr2820270119>3.0.co;2-#
Subject(s) - colonic cancer , medicine , carbohydrate , gastroenterology , pathology , cancer , colorectal cancer
Ten samples of surgically resected colonic adenocarcinomas were studied histologically and histochemically. Half of the cases showed wide structural and cytologic variations when graded according to Broders' criteria. The histochemical characteristics of the mucosubstances were found to be less variable if larger areas in a single tumor were compared with each other. The carbohydrate‐rich compounds in malignant cells differed from those of normal cells; they generally showed more intense reactions for sulfate radicals, produced neutral mucosubstances, and gave more intense periodic acid‐p‐diamine reactions. In addition to these features, which were found also in benign neoplasms, glycogen was revealed in some of the carcinoma cells which did not produce ordinary mucosubstances, and acid mucosubstances were totally or partially labile to mild sialidase digestion without previous deacetylation—features also found in embryos.