Premium
Further observations on the biologic significance of vascular invasion in Hodgkin's disease
Author(s) -
Strum Stephen B.,
Hutchison George B.,
Park Jung K.,
Rappaport Henry
Publication year - 1971
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197101)27:1<1::aid-cncr2820270102>3.0.co;2-a
Subject(s) - medicine , vascular invasion , disease , pathology , biopsy , lymph node , stage (stratigraphy) , lymph , vascular disease , cancer , biology , paleontology
Vascular invasion was detected in the pretreatment lymph node biopsy sections in 9, or 5.9%, of 153 patients with Stage I or II Hodgkin's disease. This finding was associated with a greater than twofold increase in extension of disease to nonadjacent areas and with a life‐table survival at 18 months almost one‐half that of cases without evidence of vascular invasion. Of the 9 cases of vascular invasion, 4 occurred in Hodgkin's disease of the nodular sclerosing type and 4 in Hodgkin's disease with mixed cellularity. The finding of vascular invasion in lymph node biopsy sections from patients with Hodgkin's disease regardless of histologic type appears to be a feature indicating an increased risk of the occurrence of nonadjacent or extranodal disease, or both.