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Irradiation of 'in‐situ' and invasive squamous cell carcinomas of the vagina
Author(s) -
Brown George R.,
Fletcher Gilbert H.,
Rutledge Felix N.
Publication year - 1971
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(1971)28:5<1278::aid-cncr2820280528>3.0.co;2-o
Subject(s) - medicine , vagina , cervix , pelvic exenteration , stage (stratigraphy) , vaginal vault , introitus , basal cell , pathology , surgery , cancer , biology , paleontology
Between 1948 and 1967, 34 in‐situ carcinomas and 76 invasive squamous cell carcinomas of the vagina were treated by irradiation. The results of treatment are analyzed separately for the in‐situ carcinomas and the invasive squamous carcinomas according to the classification of the International Federation of Gynecology and Obstetrics. The techniques of treatment will be described according to the location of the disease, that is vault, vaginal walls, and close to the introitus. The local control and survival rates are excellent in patients with Stage I and Stage II disease, dropping drastically in those patients with Stage III disease. In selected patients with Stage IV disease, 4,000 raads whole pelvis followed by anterior or posterior exenteration may be the treatment of choice. Particular emphasis is given to the natural history of the in‐situ carcinomas. A reappraisal of the management of these lesions is discussed, with reference to location, multiplicity, age, and sexual activity of the patients.